Shia TheBeef, or LaBeouf for those of you with French skills, is being tipped as director D.J. Caruso's first choice to play Yorick in his just turned in script for Y:The Last Man.
Y: The Last Man centers on Yorick, a twenty-something slacker and amateur escape artist, who finds himself the last surviving man after a plague kills any creature with a Y chromosome. He and Ampersand, his Capuchin monkey companion, embark on a journey to find his fiancee, Beth, in Australia, accompanied by 355, an agent of a secret government agency, and Dr. Mann, a cloning scientist who may hold the key to the plague's cure.
Alicia Keys is apparently under consideration for the role of 355. Check out the full story at SciFiWire.